Decide What You Want to Do
It's impossible to find a job if you don't know what you want to do. It is the first question you will be asked when you say that you are job hunting. If you don't have a good answer, people will be unable to effectively help you (and they may wonder how seriously you are looking for a job).
Get Support for Your Job Search
More "heads" are definitely better than one - the old cliché is absolutely true, so don't do your job search in isolation. A solitary job search can be demoralizing, and it can also be more difficult because you'll only have access to what you find by yourself. Leverage the experience, expertise, and network of friends and colleagues, and don't forget to help others, too. You will all be more successful.
Friends, outplacement counselors, your school or college's career center or placement office, members of your church (or temple or where ever you practice your religion), former co-workers, your local government, your federal government, one of the independent job hunt support groups, career counselors, and/or a job search coach can help you enormously. They will help you find resources and contacts, keep your spirits up, give you ideas, help you explore you options, and give you a boot in the pants when you need one.
Pull Together Your Resume, Including an Internet Version
Once you know the job you want and have collected information, you need to create your resume, actually, two or three versions -- for print, for e-mail, for completing online forms, and for a personal resume Web page -- with "keywords" for recruiters to find.